|Relevant historical data:|| 1934-Hilde Levi and George Charles von Hevlesy prepared he first radiocative isotope of phosporus. |
1942-Dr. Kenne administered by mouth and by injection P-32 on 27 cases of adults suffering form leukemia.
|Chemical/Radioactive Composition:|| Na2H32PO4 32S+1 32P+1H|
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|Energy Characteristics:||Maximum energy of 1.7 MeV. Average or mean 0.7 MeV.|
|Exposure Rate Constant:||P-32 is a pure beta emitter. Has no exposure rate constant.|
|Half-life Properties:||14.3 days|
|Forms available for use:||Sodium Phospate (soluble phospate) and Chromic Phospate|
|HVL in lead:||0.02 mmPb|
|Measurement/Calibrations/QA:||Seprachorm Chromatogram, or activity can be measured in a dose calibrater.|
|Used in formula/calculation:||D= 3,000mCi/70,000 g x 0.7 x 14.3 days = 31.7 cGy This is the dose given for a patient weighing 70,000 grams.|
|Uses in Radiation Oncology:||Used to treat polycythemia vera, to alleviate bone pain from breast and prostate ca, post-op for ovarian ca, malignant effusions, and now is to treat patients with grade 4 glioblastoma multiforme,|
|Treatment Planning:||No planning is done due P-32 being a beta emitter.|
|One other interesting fact:||It is interesting that in 1942 P-32 was administered in an attempt to cure leukemia. In subsequent years, due to large radiation dose to the bone marrow from P-32 injection for polycythemia vera leukemia was reported in several patients. The drug thought to cure leukemia in some cases actually caused it.|
References: Purdy, James A. Advances in Radiation Oncology Physics. Woodbury, New York: American Institute of Physics, Inc., 1992.
Selman, Joseph. The Basic Physics of Radiation Therapy. Springfield Illinois: Bannerstone House Pulblishing, 1976.