Strontium-89

Strontium 89Strontium-89 - UW-L Brachy CourseStrontium-89 - UW-L Brachy CourseStrontium-89 - UW-L Brachy CourseStrontium Strontium chloride from old chemistry set
This bottle is from a 1950's chemistry set. It's an "ATOMIC ENERGY" set (that kind of thing was big in the '50s),











Relevant historical data: Adair Crawford recognized the mineral strontianite, named after the Scottish town of Strontian, as differing from other barium minerals in 1790. However, Klaproth and Hope discovered strontium itself in 1798 and metallic strontium was first isolated by Sir Humphry Davy in 1808 using electrolysis.
Chemical/Radioactive Composition: Chemical Symbol: Sr : Mass number (A, # of protons + # of neutrons) = 89 : average energy of about 50 keV.
Energy Characteristics: Strontium-89 is a reactor product and is produced by bombarding SR 88 with Neutrons in a reactor- Sr-89 is a β-emitter and emits β-particles to form stable Y-89 having peak energy of 1.46 MeV and an average energy of 50 kev. average soft-tissue range 2.4 mm and 0.01% abundant gamma emission with a 0.91MeV photpeak.
Exposure Rate Constant: Sr-89 - 8.1585E-05- Roentgens per hour (R/hr) at a distance of one (1) meter from a one (1) curie point source
Half-life Properties: Sr-89 physical half life is 50.5 days.
Forms available for use: Metastron(Strontium 89) is administered as a simple injection (generally on an outpatient basis) by a nuclear medicine physician, radiation oncologist, or other physician licensed to administer radiopharmaceuticals for therapy. The procedure takes just a few minutes.
HVL in lead: When using beta emitters such as phosphorus 32 and strontium 89 it is necessary to use lucite as a shield to prevent the production of bremsstrahlung radiation. If dense shielding materials are used with beta emitters, the technologist will actually receive significant radiation exposure due to the bremsstrahlung radiation.
Measurement/Calibrations/QA: Once received, the activity of this isotope should be determined. The determiniation of this activity is performed with a dose calibrator that has been evaluated for linearity, constancy, and acuracy.
According to title 10, Code of Federal regulations 35, administration of an activiy of a radiopharmaceutical that differs from the prescribed activity by more than 20%(small or larger) constitutes a misadministration. If it differs between 10% to 20%, the administration constitutes a recordable event. Therefore, the activity of record of 89Sr shall be administered to the patint only if it differs by less then 10%. Compliance with the NRC regulations is mandatory.
Used in formula/calculation: a dose of 1.5 to 2.2 MBq/Kg, 40-60 uCi/Kg body weight may be used
Uses in Radiation Oncology: 89Sr is a short-lived artificial radioisotope which provides a health benefit since it substitutes for calcium in bone. In circumstances where cancer patients have widespread and painful bony metastases (secondaries), the administration of 89Sr results in the delivery of radioactive emissions (beta particles in this case) directly to the area of bony problem (where calcium turnover is greatest).
Treatment Planning: The recommended dose of Metastron is 148 MBq, 4mCi, administered by slow intravenous injection.( 1-2 minutes). Repeat administration should be based on an individuals response to therapy, current symptoms, and hematologic status, and are generally not recommended at intervals of less than 90 days.
One other interesting fact: Strontium salts impart a red color to fireworks. Strontium compounds are also important for stabilizing fireworks mixtures.


Links: http://www.iem-inc.com/toolgam.html
http://theodoregray.com/PeriodicTable/Elements/038/index.s7.html
http://interactive.snm.org/docs/pg_ch25_0403.pdf
http://www.health.state.mn.us/divs/phl/cert/maradcalcs.pdf
http://www.amershamhealth-us.com/patient/radguide/metafaq.html
http://www.websters-online-dictionary.com/definition/strontium
http://www.eanm.org/scientific_info/guidelines/gl_radio_treatment.php?navId=54
http://www.cewebsource.com/coursePDFs/Spr03RadiationSafety-NuclearMedicine.pdf
http://jnm.snmjournals.org/cgi/reprint/39/12/2110.pdf
http://chemistry.about.com/library/weekly/blfiresr.htm




References: Perez, Carlos A, Luther W. Brady, Principles and Practice of Radiation Oncology. 3rd Edition. Philadelphia: Lippcincott-Raven Publishers 1998

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